Prednisone and prednisolone are glucocorticoids which decrease aggravation and restrain safe framework reactions. They are a few times more grounded than the anxiety hormone “cortisol” which is delivered actually in a pooch’s adrenal organs and are frequently utilized for regarding Addison’s malady as a part of which your canine’s organs don’t create enough cortisol all alone. Since they smother the resistant framework they are likewise successful in the treatment of hypersensitivities and are here and there utilized as a subsequent meet-up epinephrine when puppies have endured anaphylactic stun (an exceptionally serious unfavorably susceptible response).

What’s the distinction amongst prednisone and prednisolone?

Prednisone is really a “forerunner” to prednisolone. This implies once your canine takes prednisone it is changed over by the liver into prednisolone. Consequently, vets frequently offer prednisolone to canines who have poor liver capacity to keep away from the requirement for change.

Prednisolone is likewise the best decision when your canine can’t take prescription by mouth as it is viable when given as an infusion or notwithstanding when connected topically onto the skin.

Is It Safe?

Not all canines are fit for treatment with this drug. Some of the common side effects can be uncomfortable, and it is known to cause abortion when given to pregnant pets (which is likewise the case with different glucocorticoids). It ought not be given to any puppies under 6 months of age as the immunosuppressant properties could harm.

Treatment might be unacceptable for puppies with:

  • Systemic contagious contaminations (unless utilized as substitution treatment for Addison’s infection)
  • Idiopathic thrombocytopenic purpura (when infused intramuscularly)
  • Diabetes mellitus
  • Heart disappointment

At the point when mutts get a lot of glucocorticoid for drawn out stretches of time their body reacts by closing down its own particular characteristic creation. On the off chance that this happens the adrenal organs will decay and the pooch’s body will then battle to deliver hormones even after you stop treatment. This is the reason it’s best to utilize an each other-day dosing plan at whatever point conceivable.

Safety Guidelines

Here are some important reminders to help keep your dog safe:

  • Speak to a vet before giving this medicine to your dog
  • If possible avoid using this medicine until you have a diagnosis
  • Avoid treating cancer with this drug before chemotherapy begins
  • Notify the vet of any medication or supplements your dog is on
  • Notify the vet of any medical conditions affecting your dog
  • Avoid use in pregnant pets and those under 6 months old
  • Avoid live vaccines during treatment

After longer-term treatment it’s very important that you slowly wean your dog off of the drug instead of stopping suddenly. Stopping treatment suddenly could lead to Addison’s disease.

What Is It Used For?

Prednisolone and prednisone have a wide range of potential uses but are most often used for the treatment of Addison’s disease to supplement a pet with the glucocorticoids their own body is unable to create. Because of the drug’s ability to suppress immune system responses, they are also used to control allergic reactions and autoimmune conditions such as lupus and AIHA. Here is a larger list of the possible uses of prednisone:

  • Adrenal insufficiency (Addison’s)
  • Asthma
  • Cancer (some forms)
  • High blood calcium levels
  • Central nervous system disorders
  • Skin disease
  • Arthritis
  • Shock

They are considered useful in the treatment of shock due to the ability of steroids to improve circulation.

Side Effects

Side effects from prednisone are common, but dangerous reactions do not occur as often when it is used correctly. Dogs who are taking immunosuppressive doses are more likely to suffer side effects. During treatment your dog may experience the following:


  • Increased thirst (very common)
  • Excessive urination (very common)
  • Slower wound healing
  • Increased appetite
  • Infection

Less Common

  • Vomiting
  • Diarrhea
  • Behavioral changes

 Incidence Unknown

Call the vet immediately if you notice any of these signs.

  • Shortness of breath
  • Blood in stools
  • Kidney problems
  • Coughing blood
  • Irregular heartbeat
  • Serious heart problems
  • Abdominal pain
  • Cushing’s disease
  • Addison’s disease
  • Allergic reaction

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